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Deniz Turuc robbed Juan Mata of possession and darted down the left flank, sending over a cross that Ba smartly stepped over for unopposed Visca to thump past Henderson.
United were rocked on their heels but managed to reduce the deficit with two minutes of the first half remaining. Shaw made space to swing in a fine cross from the left that Martial did well to steer home with a header.
Solskjaer surprisingly brought on Scott McTominay for the booked Tuanzebe at half-time, meaning defensive midfielder Matic dropped back to play at centre-back alongside Maguire.
Few could have foreseen this result in Istanbul, where Bruno Fernandes tried an audacious early volley from a diagonal Harry Maguire pass before Luke Shaw’s fizzing cross-shot just whizzed wide.
Basaksehir were penned back as soon as the second half got under way, with Fernandes seeing a free-kick pushed away before another shot was blocked by ex-Liverpool defender Martin Skrtel.
The former Sheffield United loanee was powerless once again to stop Edin Visca from slamming home as the Istanbul captain finished off a fine counter attack as he was also left completely on his own by the United backline.
Former Chelsea and Newcastle striker Demba Ba was left completely isolated by United’s defenders and the 36-year-old ran from his own half to slot home past Dean Henderson.
Nemanja Matic was nowhere near Ba, who controlled the ball at the halfway line and raced forward to beat European debutant Dean Henderson with a cool finish.
United attempted to remain patient when they could have panicked, but they were prosaic in possession and caught out again in the 40th minute.
But that early confidence came with a dollop of complacency, with Visca smashing over a warning shot from the edge of the box before Ba punished some dim defending.
With players waiting in the box for a cross following a short corner, United’s poor defensive structure was exploited by a ball over the top to the unmarked ex-Premier League striker.
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